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The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae
The S. cerevisiae ISR1 gene encodes a putative kinase with no ascribed function. Here, we show that Isr1 acts as a negative regulator of the highly-conserved hexosamine biosynthesis pathway (HBP), which converts glucose into uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), the carbohydrate prec...
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| Publicat a: | PLoS Genet |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7340321/ https://ncbi.nlm.nih.gov/pubmed/32579556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008840 |
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