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The Hexosamine Biosynthesis Pathway Negatively Regulates IL-2 Production by Jurkat T Cells
To test the hypothesis that the hexosamine biosynthesis pathway (HBP) affects cytokine production, we studied IL-2 production by Jurkat cells in response to PHA. We found that the HBP activator glucosamine (GlcN), but not glucose (Glc), dose-dependently reduced IL-2 production. Importantly, GlcN blo...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2007
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3178408/ https://ncbi.nlm.nih.gov/pubmed/17481598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2007.03.006 |
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