Tn-Seq reveals hidden complexity in the utilization of host-derived glutathione in Francisella tularensis

Host-derived glutathione (GSH) is an essential source of cysteine for the intracellular pathogen Francisella tularensis. In a comprehensive transposon insertion sequencing screen, we identified several F. tularensis genes that play central and previously unappreciated roles in the utilization of GSH...

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Bibliografiske detaljer
Udgivet i:PLoS Pathog
Main Authors: Ramsey, Kathryn M., Ledvina, Hannah E., Tresko, Tenayaann M., Wandzilak, Jamie M., Tower, Catherine A., Tallo, Thomas, Schramm, Caroline E., Peterson, S. Brook, Skerrett, Shawn J., Mougous, Joseph D., Dove, Simon L.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340319/
https://ncbi.nlm.nih.gov/pubmed/32492066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008566
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