Diverse patterns of antibody variable gene repertoire disruption in patients with amyloid light chain (AL) amyloidosis

Immunoglobulin light chain amyloidosis is the most common form of systemic amyloidosis. AL amyloidosis is caused by a misfolded light chain produced by a clonal population of plasma cells. Disease status currently is defined by measuring the absolute quantity of serum free light chain protein, but t...

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Udgivet i:PLoS One
Main Authors: Chen, Elaine C., Rubinstein, Samuel, Soto, Cinque, Bombardi, Robin G., Day, Samuel B., Myers, Luke, Zaytsev, Alexey, Majedi, Mahsa, Cornell, R. Frank, Crowe, James E.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340310/
https://ncbi.nlm.nih.gov/pubmed/32634163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0235713
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