The role of extracellular vesicles and PD-L1 in glioblastoma-mediated immunosuppressive monocyte induction

BACKGROUND: Immunosuppression in glioblastoma (GBM) is an obstacle to effective immunotherapy. GBM-derived immunosuppressive monocytes are central to this. Programmed cell death ligand 1 (PD-L1) is an immune checkpoint molecule, expressed by GBM cells and GBM extracellular vesicles (EVs). We sought...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Main Authors: Himes, Benjamin T, Peterson, Timothy E, de Mooij, Tristan, Garcia, Luz M Cumba, Jung, Mi-Yeon, Uhm, Sarah, Yan, David, Tyson, Jasmine, Jin-Lee, Helen J, Parney, Daniel, Abukhadra, Yasmina, Gustafson, Michael P, Dietz, Allan B, Johnson, Aaron J, Dong, Haidong, Maus, Rachel L, Markovic, Svetomir, Lucien, Fabrice, Parney, Ian F
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
Basic and Translational Investigations
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7339906/
https://ncbi.nlm.nih.gov/pubmed/32080744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa029
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