Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis

Mutations in leucine-rich repeat kinase 2 (LRRK2) are an established cause of inherited Parkinson's disease (PD). LRRK2 is expressed in both neurons and glia in the central nervous system, but its physiological function(s) in each of these cell types is uncertain. Through sequential screens, we...

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Publicado no:Neurobiol Dis
Main Authors: Heaton, George R., Landeck, Natalie, Mamais, Adamantios, Nalls, Mike A., Nixon-Abell, Jonathon, Kumaran, Ravindran, Beilina, Alexandra, Pellegrini, Laura, Li, Yan, Harvey, Kirsten, Cookson, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: Academic Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7339134/
https://ncbi.nlm.nih.gov/pubmed/32434048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.104948
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