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PBPK Modeling of Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Perchloroethylene in Mice

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD), a major cause of chronic liver disease in the Western countries with increasing prevalence worldwide, may substantially affect chemical toxicokinetics and thereby modulate chemical toxicity. OBJECTIVES: This study aims to use physiologically-base...

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Detalhes bibliográficos
Publicado no:Toxicol Appl Pharmacol
Main Authors: Dalaijamts, Chimeddulam, Cichocki, Joseph A., Luo, Yu-Syuan, Rusyn, Ivan, Chiu, Weihsueh A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7339121/
https://ncbi.nlm.nih.gov/pubmed/32445755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2020.115069
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