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PBPK Modeling of Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Perchloroethylene in Mice
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD), a major cause of chronic liver disease in the Western countries with increasing prevalence worldwide, may substantially affect chemical toxicokinetics and thereby modulate chemical toxicity. OBJECTIVES: This study aims to use physiologically-base...
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| Publicado en: | Toxicol Appl Pharmacol |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7339121/ https://ncbi.nlm.nih.gov/pubmed/32445755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2020.115069 |
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