Detection of Circulating Tumor DNA in Patients with Pancreatic Cancer Using Digital Next-Generation Sequencing

Circulating tumor DNA (ctDNA) measurements can be used to estimate tumor burden, but avoiding false-positive results is challenging. Herein, digital next-generation sequencing (NGS) is evaluated as a ctDNA detection method. Plasma KRAS and GNAS hotspot mutation levels were measured in 140 subjects,...

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Publicat a:J Mol Diagn
Autors principals: Macgregor-Das, Anne, Yu, Jun, Tamura, Koji, Abe, Toshiya, Suenaga, Masaya, Shindo, Koji, Borges, Michael, Koi, Chiho, Kohi, Shiro, Sadakari, Yoshihiko, Dal Molin, Marco, Almario, Jose A., Ford, Madeline, Chuidian, Miguel, Burkhart, Richard, He, Jin, Hruban, Ralph H., Eshleman, James R., Klein, Alison P., Wolfgang, Christopher L., Canto, Marcia I., Goggins, Michael
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7338889/
https://ncbi.nlm.nih.gov/pubmed/32205290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmoldx.2020.02.010
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