ABCB1 Genetic Variants as Predictors of Irinotecan-Induced Severe Gastrointestinal Toxicity in Metastatic Colorectal Cancer Patients

Irinotecan is widely used in the treatment of metastatic colorectal cancer (mCRC) despite its severe toxicities. Toxicity is often associated with the UGT1A1*28/*28 genotype. An explanation for idiopathic toxicity beyond the UGT1A1 biomarker, however, remains a major concern for clinicians. One of t...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Riera, Pau, Artigas-Baleri, Alícia, Salazar, Juliana, Sebio, Ana, Virgili, Anna C., Arranz, María Jesús, Páez, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7338599/
https://ncbi.nlm.nih.gov/pubmed/32695000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00973
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