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Relevance of CYP3A4*20, UGT1A1*37 and UGT1A1*28 variants in irinotecan‐induced severe toxicity
Severe irinotecan‐induced toxicity is associated with UGT1A1 polymorphisms. However, some patients develop side‐effects despite harbouring a normal UGT1A1 genotype. As CYP3A4 is also an irinotecan‐metabolizing enzyme, our study aimed to elucidate the influence of the CYP3A4*20 loss‐of‐function allel...
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| Publicado no: | Br J Clin Pharmacol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5980573/ https://ncbi.nlm.nih.gov/pubmed/29504153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13574 |
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