PD-L1 promotes tumor growth and progression by activating WIP and β-catenin signaling pathways and predicts poor prognosis in lung cancer

PD-L1 is overexpressed in tumor cells and contributes to cancer immunoevasion. However, the role of the tumor cell-intrinsic PD-L1 in cancers remains unknown. Here we show that PD-L1 regulates lung cancer growth and progression by targeting the WIP and β-catenin signaling. Overexpression of PD-L1 pr...

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Vydáno v:Cell Death Dis
Hlavní autoři: Yu, Wendan, Hua, Yijun, Qiu, Huijuan, Hao, Jiaojiao, Zou, Kun, Li, Zongjuan, Hu, Sheng, Guo, Ping, Chen, Manyu, Sui, Silei, Xiong, Yuqing, Li, Fengzhou, Lu, Jianjun, Guo, Wei, Luo, Guangyu, Deng, Wuguo
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7338457/
https://ncbi.nlm.nih.gov/pubmed/32632098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2701-z
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