Loading...
Structural insights into G domain dimerization and pathogenic mutation of OPA1
The fusion of mammalian inner mitochondrial membranes (IMMs) is mediated by dynamin-like GTPase OPA1. Mutations in human OPA1 cause optic atrophy, but the molecular basis for membrane fusion and pathogenesis is not clear. Here, we determined the crystal structure of the minimal GTPase domain (MGD) o...
Na minha lista:
| Udgivet i: | J Cell Biol |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Rockefeller University Press
2020
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7337494/ https://ncbi.nlm.nih.gov/pubmed/32379273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201907098 |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|