Mutations from bat ACE2 orthologs markedly enhance ACE2-Fc neutralization of SARS-CoV-2

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein mediates infection of cells expressing angiotensin-converting enzyme 2 (ACE2). ACE2 is also the viral receptor of SARS-CoV (SARS-CoV-1), a related coronavirus that emerged in 2002–2003. Horseshoe bats (genus Rhinoloph...

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Vydáno v:bioRxiv
Hlavní autoři: Mou, Huihui, Quinlan, Brian D., Peng, Haiyong, Guo, Yan, Peng, Shoujiao, Zhang, Lizhou, Davis-Gardner, Meredith E., Gardner, Matthew R., Crynen, Gogce, Voo, Zhi Xiang, Bailey, Charles C., Alpert, Michael D., Rader, Christoph, Choe, Hyeryun, Farzan, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337384/
https://ncbi.nlm.nih.gov/pubmed/32637954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.06.29.178459
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