Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus worldwide in a matter of months. Here we show that D614G was more infectious than the ancestral form on human lung cells, colon cells, and cells rendered permissive by ectopic expression of various mammalian ACE2 orthologs...

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出版年:bioRxiv
主要な著者: Yurkovetskiy, Leonid, Wang, Xue, Pascal, Kristen E., Tomkins-Tinch, Christopher, Nyalile, Thomas, Wang, Yetao, Baum, Alina, Diehl, William E., Dauphin, Ann, Carbone, Claudia, Veinotte, Kristen, Egri, Shawn B., Schaffner, Stephen F., Lemieux, Jacob E., Munro, James, Rafique, Ashique, Barve, Abhi, Sabeti, Pardis C., Kyratsous, Christos A., Dudkina, Natalya, Shen, Kuang, Luban, Jeremy
フォーマット: Artigo
言語:Inglês
出版事項: Cold Spring Harbor Laboratory 2020
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Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337374/
https://ncbi.nlm.nih.gov/pubmed/32637944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.07.04.187757
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