Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus worldwide in a matter of months. Here we show that D614G was more infectious than the ancestral form on human lung cells, colon cells, and cells rendered permissive by ectopic expression of various mammalian ACE2 orthologs...

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Bibliografski detalji
Izdano u:bioRxiv
Glavni autori: Yurkovetskiy, Leonid, Wang, Xue, Pascal, Kristen E., Tomkins-Tinch, Christopher, Nyalile, Thomas, Wang, Yetao, Baum, Alina, Diehl, William E., Dauphin, Ann, Carbone, Claudia, Veinotte, Kristen, Egri, Shawn B., Schaffner, Stephen F., Lemieux, Jacob E., Munro, James, Rafique, Ashique, Barve, Abhi, Sabeti, Pardis C., Kyratsous, Christos A., Dudkina, Natalya, Shen, Kuang, Luban, Jeremy
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337374/
https://ncbi.nlm.nih.gov/pubmed/32637944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.07.04.187757
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