Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus worldwide, reaching near fixation in a matter of months. Here we show that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human...

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Gepubliceerd in:Cell
Hoofdauteurs: Yurkovetskiy, Leonid, Wang, Xue, Pascal, Kristen E., Tomkins-Tinch, Christopher, Nyalile, Thomas P., Wang, Yetao, Baum, Alina, Diehl, William E., Dauphin, Ann, Carbone, Claudia, Veinotte, Kristen, Egri, Shawn B., Schaffner, Stephen F., Lemieux, Jacob E., Munro, James B., Rafique, Ashique, Barve, Abhi, Sabeti, Pardis C., Kyratsous, Christos A., Dudkina, Natalya V., Shen, Kuang, Luban, Jeremy
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier Inc. 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7492024/
https://ncbi.nlm.nih.gov/pubmed/32991842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.09.032
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