FPR1 blockade prevents receptor regulation by mitochondrial DAMPs and preserves neutrophil function after trauma

OBJECTIVES: Trauma predisposes to systemic sterile inflammation (SIRS) as well as infection, but the mechanisms linking injury to infection are poorly understood. Mitochondrial debris (MTD) contains formyl peptides (mtFPs). These bind formyl peptide receptor-1 (FPR1), trafficking neutrophils (PMN) t...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Crit Care Med
Päätekijät: Itagaki, Kiyoshi, Kaczmarek, Elzbieta, Kwon, Woon Yong, Chen, Li, Vlková, Barbora, Zhang, Quanzhi, Riça, Ingred, Yaffe, Michael B., Campbell, Yan, Marusich, Michael F., Wang, Ji Ming, Gong, Wang-Hua, Gao, Ji-Liang, Jung, Françoise, Douglas, Garry, Otterbein, Leo E., Hauser, Carl J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337247/
https://ncbi.nlm.nih.gov/pubmed/31939811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000004094
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