FPR1 blockade prevents receptor regulation by mitochondrial DAMPs and preserves neutrophil function after trauma

OBJECTIVES: Trauma predisposes to systemic sterile inflammation (SIRS) as well as infection, but the mechanisms linking injury to infection are poorly understood. Mitochondrial debris (MTD) contains formyl peptides (mtFPs). These bind formyl peptide receptor-1 (FPR1), trafficking neutrophils (PMN) t...

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Pubblicato in:Crit Care Med
Autori principali: Itagaki, Kiyoshi, Kaczmarek, Elzbieta, Kwon, Woon Yong, Chen, Li, Vlková, Barbora, Zhang, Quanzhi, Riça, Ingred, Yaffe, Michael B., Campbell, Yan, Marusich, Michael F., Wang, Ji Ming, Gong, Wang-Hua, Gao, Ji-Liang, Jung, Françoise, Douglas, Garry, Otterbein, Leo E., Hauser, Carl J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337247/
https://ncbi.nlm.nih.gov/pubmed/31939811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000004094
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