Amyotrophic Lateral Sclerosis Modifiers in Drosophila Reveal the Phospholipase D Pathway as a Potential Therapeutic Target

Amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig’s disease, is a devastating neurodegenerative disorder lacking effective treatments. ALS pathology is linked to mutations in >20 different genes indicating a complex underlying genetic architecture that is effectively unknown. Here...

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Foilsithe in:Genetics
Main Authors: Kankel, Mark W., Sen, Anindya, Lu, Lei, Theodorou, Marina, Dimlich, Douglas N., McCampbell, Alexander, Henderson, Christopher E., Shneider, Neil A., Artavanis-Tsakonas, Spyros
Formáid: Artigo
Teanga:Inglês
Foilsithe: Genetics Society of America 2020
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Investigations
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337071/
https://ncbi.nlm.nih.gov/pubmed/32345615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.119.302985
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