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TRIP13 Regulates DNA Repair Pathway Choice through REV7 Conformational Change
DNA double strand breaks (DSBs) are repaired through homology-directed repair (HDR) or non-homologous end joining (NHEJ). BRCA1/2-deficient cancers cannot perform HDR, conferring sensitivity to poly-ADP-ribose polymerase (PARP) inhibitors. However, concomitant loss of the pro-NHEJ factors 53BP1, RIF...
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| Publicado no: | Nat Cell Biol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7336368/ https://ncbi.nlm.nih.gov/pubmed/31915374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0442-y |
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