TRIP13 Regulates DNA Repair Pathway Choice through REV7 Conformational Change

DNA double strand breaks (DSBs) are repaired through homology-directed repair (HDR) or non-homologous end joining (NHEJ). BRCA1/2-deficient cancers cannot perform HDR, conferring sensitivity to poly-ADP-ribose polymerase (PARP) inhibitors. However, concomitant loss of the pro-NHEJ factors 53BP1, RIF...

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Pubblicato in:Nat Cell Biol
Autori principali: Clairmont, Connor S., Sarangi, Prabha, Ponnienselvan, Karthikeyan, Galli, Lucas D., Csete, Isabelle, Moreau, Lisa, Adelmant, Guillaume, Chowdhury, Dipanjan, Marto, Jarrod A., D’Andrea, Alan D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7336368/
https://ncbi.nlm.nih.gov/pubmed/31915374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0442-y
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