Antigen-responsive CD4(+) T cell clones contribute to the HIV-1 latent reservoir

Antiretroviral therapy suppresses but does not cure HIV-1 infection due to the existence of a long-lived reservoir of latently infected cells. The reservoir has an estimated half-life of 44 mo and is largely composed of clones of infected CD4(+) T cells. The long half-life appears to result in part...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Mendoza, Pilar, Jackson, Julia R., Oliveira, Thiago Y., Gaebler, Christian, Ramos, Victor, Caskey, Marina, Jankovic, Mila, Nussenzweig, Michel C., Cohn, Lillian B.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2020
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7336300/
https://ncbi.nlm.nih.gov/pubmed/32311008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200051
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