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Design, Synthesis and Biological Evaluation of Novel Piperazinone Derivatives as Cytotoxic Agents
Purpose: In this study, a series of piperazin-2-one derivatives were prepared through bioisosteric substitution of the imidazole ring of L-778,123 (imidazole-containing FTase inhibitor) and rearrangement of groups based on the tipifarnib structure. Final compounds were evaluated for their cytotoxic...
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| Publicado no: | Adv Pharm Bull |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Tabriz University of Medical Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7335995/ https://ncbi.nlm.nih.gov/pubmed/32665901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.34172/apb.2020.051 |
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