Contribution of Lysosome and Sigma Receptors to Neuroprotective Effects of Memantine Against Beta-Amyloid in the SH-SY5Y Cells

Purpose: Memantine is an approved drug for the treatment of Alzheimer’s disease (AD). Autophagy, lysosome dysfunction, and sigma receptors have possible roles in the pathophysiology of AD. Therefore, we aimed to investigate the contribution of sigma receptors and lysosome inhibition to the neuroprot...

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Bibliografske podrobnosti
izdano v:Adv Pharm Bull
Main Authors: Keshavarz, Mojtaba, Farrokhi, Majid Reza, Amirinezhad Fard, Elahe, Mehdipour, Mohammad
Format: Artigo
Jezik:Inglês
Izdano: Tabriz University of Medical Sciences 2020
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335986/
https://ncbi.nlm.nih.gov/pubmed/32665905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.34172/apb.2020.055
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