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Contribution of Lysosome and Sigma Receptors to Neuroprotective Effects of Memantine Against Beta-Amyloid in the SH-SY5Y Cells

Purpose: Memantine is an approved drug for the treatment of Alzheimer’s disease (AD). Autophagy, lysosome dysfunction, and sigma receptors have possible roles in the pathophysiology of AD. Therefore, we aimed to investigate the contribution of sigma receptors and lysosome inhibition to the neuroprot...

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Publicado en:Adv Pharm Bull
Autores principales: Keshavarz, Mojtaba, Farrokhi, Majid Reza, Amirinezhad Fard, Elahe, Mehdipour, Mohammad
Formato: Artigo
Lenguaje:Inglês
Publicado: Tabriz University of Medical Sciences 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335986/
https://ncbi.nlm.nih.gov/pubmed/32665905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.34172/apb.2020.055
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