Contribution of Lysosome and Sigma Receptors to Neuroprotective Effects of Memantine Against Beta-Amyloid in the SH-SY5Y Cells

Purpose: Memantine is an approved drug for the treatment of Alzheimer’s disease (AD). Autophagy, lysosome dysfunction, and sigma receptors have possible roles in the pathophysiology of AD. Therefore, we aimed to investigate the contribution of sigma receptors and lysosome inhibition to the neuroprot...

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Опубликовано в: :Adv Pharm Bull
Главные авторы: Keshavarz, Mojtaba, Farrokhi, Majid Reza, Amirinezhad Fard, Elahe, Mehdipour, Mohammad
Формат: Artigo
Язык:Inglês
Опубликовано: Tabriz University of Medical Sciences 2020
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335986/
https://ncbi.nlm.nih.gov/pubmed/32665905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.34172/apb.2020.055
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