Targeting NAD+ biosynthesis overcomes panobinostat and bortezomib-induced malignant glioma resistance

To improve therapeutic responses in glioma patients, new combination therapies that exploit a mechanistic understanding of the inevitable emergence of drug resistance are needed. Intra-tumoral heterogeneity enables a low barrier to resistance in individual glioma patients. We reasoned that targeting...

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Publicat a:Mol Cancer Res
Autors principals: Jane, Esther P., Premkumar, Daniel R., Thambireddy, Swetha, Golbourn, Brian, Agnihotri, Sameer, Bertrand, Kelsey C., Mack, Stephen C., Myers, Max I., Chattopadhyay, Ansuman, Taylor, D. Lansing, Schurdak, Mark E., Stern, Andrew M., Pollack, Ian F.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335346/
https://ncbi.nlm.nih.gov/pubmed/32238439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0669
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