Targeting NAD+ biosynthesis overcomes panobinostat and bortezomib-induced malignant glioma resistance

To improve therapeutic responses in glioma patients, new combination therapies that exploit a mechanistic understanding of the inevitable emergence of drug resistance are needed. Intra-tumoral heterogeneity enables a low barrier to resistance in individual glioma patients. We reasoned that targeting...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Jane, Esther P., Premkumar, Daniel R., Thambireddy, Swetha, Golbourn, Brian, Agnihotri, Sameer, Bertrand, Kelsey C., Mack, Stephen C., Myers, Max I., Chattopadhyay, Ansuman, Taylor, D. Lansing, Schurdak, Mark E., Stern, Andrew M., Pollack, Ian F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335346/
https://ncbi.nlm.nih.gov/pubmed/32238439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0669
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