SOCS3 is a suppressor of γc cytokine signaling and constrains generation of murine Foxp3(+) regulatory T cells

SOCS3 is a cytosolic inhibitor of cytokine signaling that suppresses the activation of cytokine receptor-associated JAK kinases. Mechanistically, SOCS3 is recruited to a site in the cytokine receptors known as the SOCS3-interaction motif, and then binds JAK molecules to inhibit their kinase activity...

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Publicat a:Eur J Immunol
Autors principals: Luckey, Megan A., Kim, Tae-Hyoun, Prakhar, Praveen, Keller, Hilary R., Crossman, Assiatu, Choi, Seeyoung, Love, Paul E., Walsh, Scott T.R., Park, Jung-Hyun
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335320/
https://ncbi.nlm.nih.gov/pubmed/32144749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201948307
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