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Suppressor of cytokine signaling 3 (SOCS-3) protects β-cells against interleukin-1β- and interferon-γ-mediated toxicity

Suppressor of cytokine signaling 3 (SOCS-3) is a negative feedback regulator of IFN-γ signaling, shown up-regulated in mouse bone marrow cells by the proinflammatory cytokines interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and IFN-γ. IL-1β and IFN-γ alone, or potentiated by TNF-α, are cyto...

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Detalhes bibliográficos
Main Authors: Karlsen, Allan E., Rønn, Sif G., Lindberg, Karen, Johannesen, Jesper, Galsgaard, Elisabeth D., Pociot, Flemming, Nielsen, Jens H., Mandrup-Poulsen, Thomas, Nerup, Jørn, Billestrup, Nils
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC59790/
https://ncbi.nlm.nih.gov/pubmed/11593036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.211445998
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