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Development and Application of TK6-derived Cells Expressing Human Cytochrome P450s for Genotoxicity Testing
Metabolism plays a key role in chemical genotoxicity; however, most mammalian cells used for in vitro genotoxicity testing lack effective metabolizing enzymes. We recently developed a battery of TK6-derived cell lines that individually overexpress 1 of 8 cytochrome P450s (CYP1A1, 1A2, 1B1, 2A6, 2B6,...
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| Veröffentlicht in: | Toxicol Sci |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7334878/ https://ncbi.nlm.nih.gov/pubmed/32159784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfaa035 |
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