Development and Application of TK6-derived Cells Expressing Human Cytochrome P450s for Genotoxicity Testing

Metabolism plays a key role in chemical genotoxicity; however, most mammalian cells used for in vitro genotoxicity testing lack effective metabolizing enzymes. We recently developed a battery of TK6-derived cell lines that individually overexpress 1 of 8 cytochrome P450s (CYP1A1, 1A2, 1B1, 2A6, 2B6,...

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Bibliographische Detailangaben
Veröffentlicht in:Toxicol Sci
Hauptverfasser: Li, Xilin, Chen, Si, Guo, Xiaoqing, Wu, Qiangen, Seo, Ji-Eun, Guo, Lei, Manjanatha, Mugimane G, Zhou, Tong, Witt, Kristine L, Mei, Nan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Genetic and Epigenetic Toxicology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7334878/
https://ncbi.nlm.nih.gov/pubmed/32159784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfaa035
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