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Structured clustering of the glycosphingolipid GM1 is required for membrane curvature induced by cholera toxin

AB(5) bacterial toxins and polyomaviruses induce membrane curvature as a mechanism to facilitate their entry into host cells. How membrane bending is accomplished is not yet fully understood but has been linked to the simultaneous binding of the pentameric B subunit to multiple copies of glycosphing...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Kabbani, Abir Maarouf, Raghunathan, Krishnan, Lencer, Wayne I., Kenworthy, Anne K., Kelly, Christopher V.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7334530/
https://ncbi.nlm.nih.gov/pubmed/32554490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2001119117
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