Mitochondrial AIF loss causes metabolic reprogramming, caspase-independent cell death blockade, embryonic lethality, and perinatal hydrocephalus

OBJECTIVES: Apoptosis-Inducing Factor (AIF) is a protein involved in mitochondrial electron transport chain assembly/stability and programmed cell death. The relevant role of this protein is underlined because mutations altering mitochondrial AIF properties result in acute pediatric mitochondriopath...

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Udgivet i:Mol Metab
Main Authors: Delavallée, Laure, Mathiah, Navrita, Cabon, Lauriane, Mazeraud, Aurélien, Brunelle-Navas, Marie-Noelle, Lerner, Leticia K., Tannoury, Mariana, Prola, Alexandre, Moreno-Loshuertos, Raquel, Baritaud, Mathieu, Vela, Laura, Garbin, Kevin, Garnier, Delphine, Lemaire, Christophe, Langa-Vives, Francina, Cohen-Salmon, Martine, Fernández-Silva, Patricio, Chrétien, Fabrice, Migeotte, Isabelle, Susin, Santos A.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7334469/
https://ncbi.nlm.nih.gov/pubmed/32480041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.101027
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