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Assays and technologies for developing proteolysis targeting chimera degraders
Targeted protein degradation by small-molecule degraders represents an emerging mode of action in drug discovery. Proteolysis targeting chimeras (PROTACs) are small molecules that can recruit an E3 ligase and a protein of interest (POI) into proximity, leading to induced ubiquitination and degradati...
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| Vydáno v: | Future Med Chem |
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| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Newlands Press Ltd
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7333641/ https://ncbi.nlm.nih.gov/pubmed/32431173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc-2020-0073 |
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