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Quantitative Middle-Down MS Analysis of Parkin-Mediated Ubiquitin Chain Assembly
Misregulation of the E3 ubiquitin ligase Parkin and the kinase PINK1 underlie both inherited and idiopathic Parkinson’s disease-associated neurodegeneration. Parkin and PINK1 work together to catalyze the assembly of ubiquitin chains on substrates located on the outer mitochondrial membrane to facil...
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| Publicat a: | J Am Soc Mass Spectrom |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7333183/ https://ncbi.nlm.nih.gov/pubmed/32297515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jasms.0c00058 |
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