Genetic and Functional Analyses Point to FAN1 as the Source of Multiple Huntington Disease Modifier Effects

A recent genome-wide association study of Huntington disease (HD) implicated genes involved in DNA maintenance processes as modifiers of onset, including multiple genome-wide significant signals in a chr15 region containing the DNA repair gene Fanconi-Associated Nuclease 1 (FAN1). Here, we have carr...

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Udgivet i:Am J Hum Genet
Main Authors: Kim, Kyung-Hee, Hong, Eun Pyo, Shin, Jun Wan, Chao, Michael J., Loupe, Jacob, Gillis, Tammy, Mysore, Jayalakshmi S., Holmans, Peter, Jones, Lesley, Orth, Michael, Monckton, Darren G., Long, Jeffrey D., Kwak, Seung, Lee, Ramee, Gusella, James F., MacDonald, Marcy E., Lee, Jong-Min
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7332667/
https://ncbi.nlm.nih.gov/pubmed/32589923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2020.05.012
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