Altered iron metabolism in cystic fibrosis macrophages: the impact of CFTR modulators and implications for Pseudomonas aeruginosa survival

Cystic fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene, resulting in chronic bacterial lung infections and tissue damage. CF macrophages exhibit reduced bacterial killing and increased inflammatory signaling. Iron is elevated in the CF...

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Publicado no:Sci Rep
Main Authors: Hazlett, H. F., Hampton, T. H., Aridgides, D. S., Armstrong, D. A., Dessaint, J. A., Mellinger, D. L., Nymon, A. B., Ashare, A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7331733/
https://ncbi.nlm.nih.gov/pubmed/32616918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67729-5
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