PPARα activation directly upregulates thrombomodulin in the diabetic retina

Two large clinical studies showed that fenofibrate, a commonly used peroxisome proliferator-activated receptor α (PPARα) agonist, has protective effects against diabetic retinopathy. However, the underlying mechanism has not been clarified. We performed genome-wide analyses of gene expression and PP...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Shiono, Akira, Sasaki, Hiroki, Sekine, Reio, Abe, Yohei, Matsumura, Yoshihiro, Inagaki, Takeshi, Tanaka, Toshiya, Kodama, Tatsuhiko, Aburatani, Hiroyuki, Sakai, Juro, Takagi, Hitoshi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7331602/
https://ncbi.nlm.nih.gov/pubmed/32616724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67579-1
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