Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/β-catenin signaling

CATSHL syndrome, characterized by camptodactyly, tall stature and hearing loss, is caused by loss-of-function mutations of fibroblast growth factor receptors 3 (FGFR3) gene. Most manifestations of patients with CATSHL syndrome start to develop in the embryonic stage, such as skeletal overgrowth, cra...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Sun, Xianding, Zhang, Ruobin, Chen, Hangang, Du, Xiaolan, Chen, Shuai, Huang, Junlan, Liu, Mi, Xu, Meng, Luo, Fengtao, Jin, Min, Su, Nan, Qi, Huabing, Yang, Jing, Tan, Qiaoyan, Zhang, Dali, Ni, Zhenhong, Liang, Sen, Zhang, Bin, Chen, Di, Zhang, Xin, Luo, Lingfei, Chen, Lin, Xie, Yangli
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7330844/
https://ncbi.nlm.nih.gov/pubmed/32641982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.45286
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