Identification of a Broad-Spectrum Viral Inhibitor Targeting a Novel Allosteric Site in the RNA-Dependent RNA Polymerases of Dengue Virus and Norovirus

All RNA viruses encode the RNA-dependent RNA polymerase (RdRp) which replicates and transcribes viral RNA. This essential viral enzyme does not exist in mammalian cells, thus presents a main target for the development of antiviral drugs with potential pan-antiviral activity. In this study, we take a...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Yi, Dongrong, Li, Quanjie, Pang, Lili, Wang, Yujia, Zhang, Yongxin, Duan, Zhaojun, Liang, Chen, Cen, Shan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7330483/
https://ncbi.nlm.nih.gov/pubmed/32670253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2020.01440
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