A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase

Antiviral therapeutics is one effective avenue to control and end this devastating COVID-19 pandemic. The viral RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 has been recognized as a valuable target of antivirals. However, the cell-free SARS-CoV-2 RdRp biochemical assay requires the conversion o...

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Publicado en:Antiviral Res
Autores principales: Zhao, Jianyuan, Guo, SaiSai, Yi, Dongrong, Li, Quanjie, Ma, Ling, Zhang, Yongxin, Wang, Jing, Li, Xiaoyu, Guo, Fei, Lin, Rongtuan, Liang, Chen, Liu, Zhenlong, Cen, Shan
Formato: Artigo
Lenguaje:Inglês
Publicado: The Authors. Published by Elsevier B.V. 2021
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8059291/
https://ncbi.nlm.nih.gov/pubmed/33894278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2021.105078
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