A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction

Osteocytes, cells ensconced within mineralized bone matrix, are the primary skeletal mechanosensors. Osteocytes sense mechanical cues by changes in fluid flow shear stress (FFSS) across their dendritic projections. Loading-induced reductions of osteocytic Sclerostin (encoded by Sost) expression stim...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Sato, Tadatoshi, Verma, Shiv, Andrade, Christian D. Castro, Omeara, Maureen, Campbell, Nia, Wang, Jialiang S., Cetinbas, Murat, Lang, Audrey, Ausk, Brandon J., Brooks, Daniel J., Sadreyev, Ruslan I., Kronenberg, Henry M., Lagares, David, Uda, Yuhei, Pajevic, Paola Divieti, Bouxsein, Mary L., Gross, Ted S., Wein, Marc N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7329900/
https://ncbi.nlm.nih.gov/pubmed/32612176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17099-3
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