Integration of Placental Transfer in a Fetal–Maternal Physiologically Based Pharmacokinetic Model to Characterize Acetaminophen Exposure and Metabolic Clearance in the Fetus

BACKGROUND AND OBJECTIVE: Although acetaminophen is frequently used during pregnancy, little is known about fetal acetaminophen pharmacokinetics. Acetaminophen safety evaluation has typically focused on hepatotoxicity, while other events (fetal ductal closure/constriction) are also relevant. We aime...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Clin Pharmacokinet
Egile Nagusiak: Mian, Paola, Allegaert, Karel, Conings, Sigrid, Annaert, Pieter, Tibboel, Dick, Pfister, Marc, van Calsteren, Kristel, van den Anker, John N., Dallmann, André
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer International Publishing 2020
Gaiak:
Original Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7329787/
https://ncbi.nlm.nih.gov/pubmed/32052378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-020-00861-7
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