Integration of Placental Transfer in a Fetal–Maternal Physiologically Based Pharmacokinetic Model to Characterize Acetaminophen Exposure and Metabolic Clearance in the Fetus

BACKGROUND AND OBJECTIVE: Although acetaminophen is frequently used during pregnancy, little is known about fetal acetaminophen pharmacokinetics. Acetaminophen safety evaluation has typically focused on hepatotoxicity, while other events (fetal ductal closure/constriction) are also relevant. We aime...

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Detalles Bibliográficos
Publicado en:Clin Pharmacokinet
Main Authors: Mian, Paola, Allegaert, Karel, Conings, Sigrid, Annaert, Pieter, Tibboel, Dick, Pfister, Marc, van Calsteren, Kristel, van den Anker, John N., Dallmann, André
Formato: Artigo
Idioma:Inglês
Publicado: Springer International Publishing 2020
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Original Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7329787/
https://ncbi.nlm.nih.gov/pubmed/32052378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-020-00861-7
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