Physiologically Based Pharmacokinetic Modeling to Characterize Acetaminophen Pharmacokinetics and N-Acetyl-p-Benzoquinone Imine (NAPQI) Formation in Non-Pregnant and Pregnant Women

BACKGROUND AND OBJECTIVE: Little is known about acetaminophen (paracetamol) pharmacokinetics during pregnancy. The aim of this study was to develop a physiologically based pharmacokinetic (PBPK) model to predict acetaminophen pharmacokinetics throughout pregnancy. METHODS: PBPK models for acetaminop...

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Опубликовано в: :Clin Pharmacokinet
Главные авторы: Mian, Paola, van den Anker, John N., van Calsteren, Kristel, Annaert, Pieter, Tibboel, Dick, Pfister, Marc, Allegaert, Karel, Dallmann, André
Формат: Artigo
Язык:Inglês
Опубликовано: Springer International Publishing 2019
Предметы:
Original Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994454/
https://ncbi.nlm.nih.gov/pubmed/31347013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-019-00799-5
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