An Indole Derivative Protects Against Acetaminophen-Induced Liver Injury by Directly Binding to N-Acetyl-p-Benzoquinone Imine in Mice

Aims: Acetaminophen (APAP)-induced liver injury is mainly due to the excessive formation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) through the formation of a reactive intermediate, N-acetyl-p-benzoquinone imine (NAPQI), in both humans and rodents. Here, we show that the in...

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Detalhes bibliográficos
Main Authors: Park, Ji-Hoon, Seo, Kang-Sik, Tadi, Surendar, Ahn, Bong-Hyun, Lee, Jung-Uee, Heo, Jun-Young, Han, Jeongsu, Song, Myoung-Sub, Kim, Soon-Ha, Yim, Yong-Hyeon, Choi, Hueng-Sik, Shong, Minho, Kweon, GiRyang
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Original Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619205/
https://ncbi.nlm.nih.gov/pubmed/23121402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2012.4677
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