Effect of Aβ Oligomers on Neuronal APP Triggers a Vicious Cycle Leading to the Propagation of Synaptic Plasticity Alterations to Healthy Neurons

Alterations of excitatory synaptic function are the strongest correlate to the pathologic disturbance of cognitive ability observed in the early stages of Alzheimer's disease (AD). This pathologic feature is driven by amyloid-β oligomers (Aβos) and propagates from neuron to neuron. Here, we inv...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Rolland, Marta, Powell, Rebecca, Jacquier-Sarlin, Muriel, Boisseau, Sylvie, Reynaud-Dulaurier, Robin, Martinez-Hernandez, Jose, André, Louise, Borel, Eve, Buisson, Alain, Lanté, Fabien
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7329309/
https://ncbi.nlm.nih.gov/pubmed/32444385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2501-19.2020
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