Transplantation tolerance modifies donor-specific B cell fate to suppress de novo alloreactive B cells

The absence of alloantibodies is a feature of transplantation tolerance. Although the lack of T cell help has been evoked to explain this absence, herein we provide evidence for B cell–intrinsic tolerance mechanisms. Using a murine model of heart tolerance, we showed that alloreactive B cells were n...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Khiew, Stella H.W., Jain, Dharmendra, Chen, Jianjun, Yang, Jinghui, Yin, Dengping, Young, James S., Dent, Alexander, Sciammas, Roger, Alegre, Maria-Luisa, Chong, Anita S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7329196/
https://ncbi.nlm.nih.gov/pubmed/32452834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI132814
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