A conserved, N-terminal tyrosine signal directs Ras for inhibition by Rabex-5

Dysregulation of the Ras oncogene in development causes developmental disorders, “Rasopathies,” whereas mutational activation or amplification of Ras in differentiated tissues causes cancer. Rabex-5 (also called RabGEF1) inhibits Ras by promoting Ras mono- and di-ubiquitination. We report here that...

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Publicat a:PLoS Genet
Autors principals: Washington, Chalita, Chernet, Rachel, Gokhale, Rewatee H., Martino-Cortez, Yesenia, Liu, Hsiu-Yu, Rosenberg, Ashley M., Shahar, Sivan, Pfleger, Cathie M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7329146/
https://ncbi.nlm.nih.gov/pubmed/32559233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008715
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