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A conserved, N-terminal tyrosine signal directs Ras for inhibition by Rabex-5
Dysregulation of the Ras oncogene in development causes developmental disorders, “Rasopathies,” whereas mutational activation or amplification of Ras in differentiated tissues causes cancer. Rabex-5 (also called RabGEF1) inhibits Ras by promoting Ras mono- and di-ubiquitination. We report here that...
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| Foilsithe in: | PLoS Genet |
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| Main Authors: | , , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Public Library of Science
2020
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7329146/ https://ncbi.nlm.nih.gov/pubmed/32559233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008715 |
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